Look Who's Turning 40 and 50

As strong and sexy as when she first hit the hip-hop scene, she’s a woman who has no interest in being taken for a girl.

The Duchess of York—a.k.a. the first Fergie—is a champion reinventor, becoming both a weight-loss spokeswoman and a best-selling children’s book author after her royal marriage dissolved.

As “Stacy’s Mom,” she had it goin’ on. At 40, this New Zealand-born model still does.

Our favorite C Z-J moment? Accepting her Oscar—even performing a song—while very pregnant, with style to spare.

The woman who, as Grey’s Anatomy’s inimitable Dr. Bailey, officially introduced vajayjay to the lexicon is someone we’re thrilled to have on our team.

“I want a big rock concert for my fiftieth birthday,” the actress (and inspiration for the Toto song “Rosanna”) told MORE last year.

She’s got an Oscar, a Tony—and now a milestone birthday to celebrate!

J.Lo, Jenny From the Block—whatever the moniker, she’s right up there with Madonna as a mother of reinvention.

The singer-songwriter, a longtime member of Amnesty International, has had hits such as “Luka” and “Tom’s Diner” covered and remixed by other influential artists.

What would House do to celebrate a milestone birthday like Laurie’s? Probably alienate his patients, fantasize about Cuddy and treat himself to a few extra painkillers. Pretty much like any other day, then. We’re sure Laurie has something much less misanthropic planned.

Since her retirement 10 years ago, this tennis champion—called the greatest female player of all time by Billie Jean King—now focuses on her two kids (with husband Andre Agassi) and the charity she founded, Children for Tomorrow.

Not only is the NBC Nightly News anchor smart and reassuring, but he was one of the best Saturday Night Live hosts in years. Who could ask for more?

The rapper/actor/producer is reportedly working on a big-screen adaptation of Welcome Back, Kotter. From gangstas to Sweathogs in 20 years—who’d have thunk it?

She has played Elizabeth I, Katharine Hepburn and Bob Dylan. With all that history under her belt, it’s about time she turned 40.

If her personal life has been a bit of a soap opera, well, she did start out on Another World. But who cares? She’s always riveting.