The Many Moods of Perimenopause

How to cope with mood swings and hormone fluctuations related to perimenopause and menopause.

By Alice Lesch Kelly
woman menopause picture

Perimenopause and Depression

If you’ve ever felt grumpy around the time of your period, you know firsthand that hormone fluctuations can have an impact on your mood. The same thing can happen during perimenopause — but in this time of up-and-down hormone levels, the chance of having mood swings and your risk of depression increase.

Occasionally you may feel anger, anxiety, and irritability, but not enough to interfere with or decrease your quality of life. And then there are women who feel downright liberated by the freedoms that come with perimenopause and, even more, when menstrual periods stop completely. "There is the freedom from fear of pregnancy, which for some women increases the pleasure of intimacy with their partner," says ob-gyn Jan Herr, MD, a menopause expert at Kaiser Permanente Northern California. Menopause puts an end to PMS and to the cyclic changes in appetite and mood, menstrual headaches, and cramping that plague so many women. Best of all, there’s no more monthly bleeding. "At last, you can wear white pants with impunity," she says.

For some of us, however, mood swings are a real concern, and the overall rate of depression during perimenopause does rise substantially. Although the majority of us experience no serious mood problems during perimenopause, depression is about four times more likely to strike now than during other times of a woman’s life.

Women are more likely to experience symptoms in perimenopause even if they have no lifetime history of major depression, according to the Harvard Study of Moods and Cycles. In this 2006 project, researchers followed 644 women between the ages of 36 and 44. The 365 women in the study who entered perimenopause during the observation period were two times more likely to develop depressive symptoms than women of the same age who were not perimenopausal. "Depression is one of the most important public health problems facing perimenopausal women today," says Bernard L. Harlow, PhD, professor of epidemiology and community health at the University of Minnesota School of Public Health and a lead researcher on the study.

The Harvard study also looked at the connection between hot flashes and depression. Researchers discovered that for perimenopausal women who experienced hot flashes, the risk of depression was more than double that of the women without hot flashes. When researchers reclassified the women who entered perimenopause based on whether they used hormonal therapy to ease symptoms, they saw a similar association between the menopausal transition and the risk of new depressive symptoms. The percentage of women experiencing severe depressive symptoms for the first time was greater for those who did not use hormones. Women who used hormones were still as likely to develop depressive symptoms, but they had a somewhat decreased risk of actually developing depression.

There’s more. Women with a history of major depression and chronic PMS are more likely to experience depression during perimenopause, develop symptoms such as hot flashes and menstrual cycle changes, and begin the transition earlier than those who have never had depression.

However, when it comes to mood and hormones, it’s something of a chicken-and-egg situation: Do women with early perimenopause get depressed, or does depression cause an early transition? Do hormones trigger depression, or does depression alter the action of hormones? "It’s very possible that depression impacts the normal production of hormones tied to reproduction, especially those in the brain," Harlow says.

Whatever the reasons for perimenopausal depression, if the quality of your life is being seriously affected by feelings of sadness, irritability, or anxiety, see your doctor. "If you notice symptoms of depression, get treatment," says Jan Shifren, MD, director of the Vincent Menopause Program at Massachusetts General Hospital, in Boston. "Don’t just say ‘it will pass.’"

You may be treated with several different types of medication, including hormone therapy, birth control pills, and antidepressants. Hormone therapy may help alleviate depression. Birth control pills help some women because they stabilize erratic hormone levels.

Share Your Thoughts!


Vaileria Dennis09.19.2014

Mood disorder is a less severe form of depression. Although less extreme, dysthymic disorder causes chronic of long-lasting moodiness. With dysthymic disorder, low, dark moods invade your life nearly every day for two years or more. When I was suffering from mood swings, I have taken Trainqulene and it relived my mood problems and help me to relax and feel positive. But before taking any medicine during pregnancy it is important to consult with doctor. Here is information with proper rating and helpful reviews

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