Bradley Cooper & Sandra Bullock
1 / 15VIEW ALL
It was never actually confirmed, but rumors swirled in 2011 that Sandra Bullock and Bradley Cooper were a couple. All we know for sure is the pair had no romantic chemistry while co-starring in the 2009 flop All About Steve.
Tom Cruise & Nicole Kidman
2 / 15VIEW ALL
One of the most highly publicized marriages in Hollywood history was between Tom Cruise & Nicole Kidman, but this former power couple lacked magic in the thriller Eyes Wide Shut and adventure epic Far and Away.
Madonna & Sean Penn
3 / 15VIEW ALL
When Madonna and Sean Penn co-starred in the 1986 crime-adventure Shanghai Surprise, it was as disappointing as their four-year marriage. If the couple was as mismatched in real life as they were on-screen, that could explain a lot.
Jim Carrey & Renee Zellweger
4 / 15VIEW ALL
Whatever romantic chemistry Jim Carrey and Renee Zellweger had when they dated (1999-2000) went undetected by moviegoers. Thankfully the offbeat pairing didn't stop their film, Me, Myself & Irene, from making a lot of money.
Ted Danson & Mary Steenburgen
5 / 15VIEW ALL
After more than 20 years of marriage, celebrity couple Ted Danson and Mary Steenburgen obviously have something special. Unfortunately, it doesn't translate to their on-screen collaborations, such as 1994's Pontiac Moon, the film that first brought them together.
Julia Roberts & Kiefer Sutherland
6 / 15VIEW ALL
When Julia Roberts was engaged to Kiefer Sutherland, they appeared together in the 1990 horror flick Flatliners. The couple's on-screen incompatibility wasn't the only reason the film flopped but it didn't help; and the relationship flatlined months later.
Will Smith & Jada Pinkett Smith
7 / 15VIEW ALL
When Will Smith played Muhammad Ali in the 2001 biopic Ali, he was worried about being convincing in the role, but it was the on-screen romance with co-star and real-life wife Jada Pinkett Smith that seemed bogus.
Steve Martin & Victoria Tennant
8 / 15VIEW ALL
Steve Martin and British actress Victoria Tennant met on the set of 1984's All of Me and soon married. Before divorcing, the celebrity couple also starred in L.A. Story, but they never seemed like a romantic match, especially on-screen.
Matt Damon & Minnie Driver
9 / 15VIEW ALL
One of the few things wrong with Good Will Hunting was the on-screen pairing of real-life couple Matt Damon and Minnie Driver. These talented actors couldn't quite convince us they were right for each other.
Natalie Wood & Robert Wagner
10 / 15VIEW ALL
They may have been Hollywood's golden couple during their two marriages, but the on-screen collaborations of legendary actors Natalie Wood and Robert Wagner were disastrous; particularly in the much-ridiculed 1960 drama All the Fine Young Cannibals.
Al Pacino & Diane Keaton
11 / 15VIEW ALL
The Godfather ultimately wasn't hurt much by the decision to cast Diane Keaton as Kay, the wife of Al Pacino's character, Michael Corleone. But in their scenes together, this on-screen relationship seems as improbable as the actors' real-life romance.
Tom Hanks & Rita Wilson
12 / 15VIEW ALL
Tom Hanks and Rita Wilson have been married for 28 years and always appear to have a special bond, except when they co-star in films together. Among the numerous projects they've collaborated on is the forgettable 1985 comedy Volunteers.
Warren Beatty & Annette Bening
13 / 15VIEW ALL
They may have had a certain spark in the 1991 biopic Bugsy but by the time Warren Beatty and Annette Bening co-starred in Love Affair, after they married, the on-screen chemistry was gone.
Melanie Griffith & Antonio Banderas
14 / 15VIEW ALL
They were married for 21 years, but no one who saw Antonio Banderas and Melanie Griffith share the screen in the 2014 sci-fi thriller flop Automata would be surprised by their recent divorce.
Ben Affleck & Jennifer Lopez
15 / 15VIEW ALL
Possibly the best example of a real-life couple's chemistry failing to resonate on the big screen is the notoriously bad 2003 comedy Gigli starring Jennifer Lopez and Ben Affleck, who ended their engagement within months of the disappointing release.